Interstate 22: Tupelo Mississippi to Birmingham Alabama

🚙 Drive America’s Highways for 127 miles east along Interstate 22 from Tupelo Mississippi to Birmingham Alabama.

We start the video merging onto Interstate 22 at a cloverleaf interchange with U.S. Highway 45 north of Tupelo. Driving generally east, we continue along I-22 through Fulton and Tremont before reaching the Alabama State Line (7:55).

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Entering Alabama, Interstate 22 turns southeast just before Hamilton. Continuing southeast, we pass the Interchanges with U.S. Highway 278 and Alabama Highway 13 before reaching Jasper, where the road becomes a little bit more southerly in its direction. Passing through Cordova, we once again turn southeast to cross the interchange with U.S. Highway 78 in Graysville.

Staying eastbound on I-22, we cross 4 local interchanges before reaching the eastern terminus of Interstate 22 at an interchange with Interstate 65 north of Birmingham where we end the video turning southbound.

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