Drive America’s Highways for 59 miles west along U.S. Highway 278 from Tupelo to Oxford, Mississippi.
Tupelo
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Natchez Trace Parkway: Tupelo – Mississippi
Drive America’s Highways for 7 miles south along the Natchez Trace Parkway in Tupelo, Mississippi
Interstate 22: Birmingham to Tupelo – Alabama/Mississippi
Drive America’s Highways for 128 miles west along Interstate 22 from Birmingham to Tupelo.
![[Revisited] Interstate 22: Tupelo to Birmingham – Mississippi/Alabama](https://interstate411.us/wp-content/uploads/2024/09/p49_zamwykgmaxresdefault-400x250.jpg)
[Revisited] Interstate 22: Tupelo to Birmingham – Mississippi/Alabama
Drive America’s Highways for 128 miles east along Interstate 22 from Tupelo to Birmingham.
![[Revisited] Natchez Trace Parkway: Northbound through Tupelo – Mississippi](https://interstate411.us/wp-content/uploads/2024/09/5wd8xrx2zeimaxresdefault-400x250.jpg)
[Revisited] Natchez Trace Parkway: Northbound through Tupelo – Mississippi
Drive America’s Highways for 9 miles north along the Natchez Trace Parkway in Tupelo, Mississippi
U.S. Route 278: Oxford to Tupelo – Mississippi
Drive America’s Highways for 59 miles east along U.S. Highway 278 from Oxford to Tupelo, Mississippi.
Interstate 22: Tupelo Mississippi to Birmingham Alabama
Drive America’s Highways for 127 miles east along Interstate 22 from Tupelo, Mississippi to Birmingham, Alabama.
Northbound U.S. Highway 45 in Tupelo – Mississippi
Drive America’s Highways for 3 miles along Northbound U.S. Highway 45 in Tupelo, Mississippi
Drive to Elvis’ Birthplace from Interstate 22 in Tupelo, Mississippi
🚙 Drive America’s Highways for 2 miles south along Veterans Memorial Boulevard as we drive to Elvis’ Birthplace from Interstate 22 in Tupelo, Mississippi.