Northbound U.S. Highway 45 in Tupelo – Mississippi

🚙 Drive America’s Highways for 3 miles along Northbound U.S. Highway 45 in Tupelo, Mississippi.

We start the video entering U.S. Highway 45 from the main street interchange just east of downtown Tupelo. Driving north, we soon turn northwest to reach the interchange with MS-178, where we continue northbound on U.S. 45. A mile or two later, we reach the interchange with Interstate 22, where we end the video turning eastbound onto I-22.


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