The segment of Interstate 49 between Springdale and Pineville begins at the interchange with U.S. Route 412 in Springdale, Arkansas. Travelling initially north, the highway turns northeast to intersect the newly constructed Arkansas Highway 612 at a partially constructed stack interchange. Passing AR-612, the highway turns north once again to pass through Lowell and enter Rogers where the road turns northwest briefly before turning north again just before the New Hope Rd interchange.
Leaving Rogers near the U.S. Route 62 interchange, the highway enters Bentonville and turns northwest to cross the U.S. Route 71 interchange and become the Bella Vista Bypass. Continuing west out of Bentonville, I-49 turns north once again at the interchange with AR-72 where it travels another 5 miles to the Missouri border.
Entering Missouri, 49 crosses an interchange with Missouri State Route 90 before reaching a partial interchange with U.S. Route 71. Continuing northbound, the segment ends at the interchange with Missouri Supplemental Route H at Pineville.