Drive Ohio State Route 48 from downtown Dayton to Englewood along Main Street, crossing the Great Miami River and northern Montgomery County.

Beginning in Arkansas and climbing through the Missouri Ozarks, this Spring 2026 journey follows U.S. Route 67 to St. Louis before crossing the Midwest on Interstate 70 to Dayton, Ohio. Along the way, the route connects river towns, rolling farmland, major metropolitan centers, and some of America's busiest transportation corridors. The return trip charts a different course through Ohio, Kentucky, Indiana, and Tennessee, creating a broad loop through the heart of the Midwest. From the Mississippi River to the Miami Valley, this drive offers a diverse look at the landscapes, communities, and highways that tie the region together.

Drive Ohio State Route 48 from downtown Dayton to Englewood along Main Street, crossing the Great Miami River and northern Montgomery County.

Drive Interstate 70 from Indianapolis to Richmond, Indiana, through downtown interchanges, central Indiana farmland, historic towns, and the Ohio state line.

Travel Interstate 70 from Terre Haute to Indianapolis, Indiana, on a 77-mile real-time drive through farmland, small towns, Plainfield, and the western Indianapolis metro.

Drive Interstate 70 from St. Louis to Effingham, Illinois, crossing the Mississippi River and traveling through the Metro East, Greenville, Vandalia, Altamont, and southern Illinois farmland.

Drive 4th Street north through downtown St. Louis from Gratiot Street to Convention Plaza and Broadway past stadium, hotel, office, and convention district blocks.

Drive north on Interstate 55 from Festus to St. Louis, Missouri, following a 34-mile route from the U.S. Route 67 interchange through Jefferson County, South County, and into the city at I-44.

Drive U.S. Route 67 from Bonne Terre to Festus, Missouri, through wooded hills, rural Jefferson County, St. Francois State Park, and the I-55 corridor.

Drive U.S. Route 67 from Farmington to Bonne Terre, Missouri, through Lead Belt communities, wooded hills, and St. Francois State Park.

Drive U.S. Route 67 from Fredericktown to Farmington, Missouri, through 18 miles of wooded Ozark hills, rural countryside, and Lead Belt scenery.

Drive U.S. Route 67 from Poplar Bluff to Fredericktown through Greenville, Cherokee Pass, and the forested hills of Missouriβs eastern Ozarks.

Drive north on U.S. Route 67 from Corning, Arkansas to Poplar Bluff, Missouri, crossing the Arkansas Delta into the wooded foothills of southeast Missouri on this scenic 30-mile journey through farm country, small towns, and historic highway landscapes.

The Dayton trip videos drop tomorrow with fresh formatting! Plus, we’re already planning our next Kentucky and Route 66 run.