Drive Interstate 70 from St. Louis to Effingham, Illinois, crossing the Mississippi River and traveling through the Metro East, Greenville, Vandalia, Altamont, and southern Illinois farmland.
🚜 Midwest
Explore scenic road trips across the Midwest, including IA, MO, IL, IN, OH, MN, WI, and MI. Discover farmland highways, lakefront routes, and classic Americana.
The Midwest is the crossroads of America—a region where long, open highways meet friendly towns, rolling farmland, and Great Lakes shorelines. Covering Iowa, Missouri, Illinois, Indiana, Ohio, Minnesota, Wisconsin, and Michigan, the Midwest offers a rich blend of rural charm, industrial heritage, and natural beauty. Whether you're navigating the wide cornfields of Iowa or hugging the rocky shores of Lake Superior, the region’s roads are built for exploration.
This is where iconic byways like Historic Route 66 and the Great River Road converge with scenic loops around glacial lakes and wooded hills. In places like southern Missouri and northern Wisconsin, the terrain becomes unexpectedly dramatic—filled with bluffs, rivers, and forested stretches. Meanwhile, cities like Chicago, Minneapolis, St. Louis, and Cleveland serve as vibrant urban hubs offering cultural detours, architectural wonders, and food scenes worth the stop.
From Michigan’s winding coastal routes and ferry-linked peninsulas to Ohio’s Amish country and Indiana’s covered bridge trails, the Midwest is full of surprises. It’s a region best experienced slowly, with the windows down and a cooler in the backseat. These are the roads that define the heartland—and they’re ready for your next great American drive.
States in the Midwest 🚜
Explore 🚜 Midwest
4th St: St. Louis, Missouri
Drive 4th Street north through downtown St. Louis from Gratiot Street to Convention Plaza and Broadway past stadium, hotel, office, and convention district blocks.
Interstate 55: Festus to St. Louis, Missouri
Drive north on Interstate 55 from Festus to St. Louis, Missouri, following a 34-mile route from the U.S. Route 67 interchange through Jefferson County, South County, and into the city at I-44.
U.S. Route 67: Bonne Terre to Festus, Missouri
Drive U.S. Route 67 from Bonne Terre to Festus, Missouri, through wooded hills, rural Jefferson County, St. Francois State Park, and the I-55 corridor.
U.S. Route 67: Farmington to Bonne Terre, Missouri
Drive U.S. Route 67 from Farmington to Bonne Terre, Missouri, through Lead Belt communities, wooded hills, and St. Francois State Park.
U.S. Route 67: Fredericktown to Farmington, Missouri
Drive U.S. Route 67 from Fredericktown to Farmington, Missouri, through 18 miles of wooded Ozark hills, rural countryside, and Lead Belt scenery.
U.S. Route 67: Poplar Bluff to Fredericktown, Missouri
Drive U.S. Route 67 from Poplar Bluff to Fredericktown through Greenville, Cherokee Pass, and the forested hills of Missouri’s eastern Ozarks.
U.S. Route 67: Corning, Arkansas to Poplar Bluff, Missouri
Drive north on U.S. Route 67 from Corning, Arkansas to Poplar Bluff, Missouri, crossing the Arkansas Delta into the wooded foothills of southeast Missouri on this scenic 30-mile journey through farm country, small towns, and historic highway landscapes.
![[Revisited] Interstate 75: Dayton to Cincinnati, Ohio](https://media.openroadarchive.com/file/ora-media/uploads/2026/03/oukqs84qbtwmaxresdefault.webp)
[Revisited] Interstate 75: Dayton to Cincinnati, Ohio
Drive Interstate 75 from Dayton to Cincinnati, Ohio, covering 63 miles of busy urban freeway, suburban growth, and key Midwest infrastructure. Experience one of Ohio’s most important transportation corridors connecting aviation history, industry, and river city landscapes.
Interstate 75: Toledo to Dayton, Ohio
Drive Interstate 75 from Toledo to Dayton, Ohio, a 152-mile journey through northwest Ohio farmland, historic canal towns like Wapakoneta and Sidney, and major Midwest cities shaped by aviation and industry.
Interstate 75: Monroe, Michigan to Toledo, Ohio
Drive 11 miles south on Interstate 75 from Monroe, Michigan to the Ohio state line toward Toledo. This short interstate segment crosses the flat Lake Erie plain, connecting southeastern Michigan farmland with the busy Toledo metropolitan corridor along one of America’s most important north–south highways.
Interstate 69: Indianapolis to Alexandria, Indiana
Drive Interstate 69 from Indianapolis to Alexandria, Indiana, covering 50 miles of urban-to-rural transition through Hamilton and Madison counties, ending at the Pipe Creek Rest Area.