Interstate 29 is an Interstate Highway in the Midwestern United States. I-29 runs from Kansas City, Missouri, at a junction with I-35 and I-70, to the Canada–US border near Pembina, North Dakota, where it connects with Manitoba Provincial Trunk Highway 75 (PTH 75), which continues on to Winnipeg.
The road follows the course of three major rivers, all of which form the borders of US states. The southern portion of I-29 closely parallels the Missouri River from Kansas City northward to Sioux City, Iowa, where it crosses and then parallels the Big Sioux River. For the northern third of the highway, it closely follows the Red River of the North.
The major cities that I-29 connects to includes (from south to north) Council Bluffs, Iowa; Sioux Falls, South Dakota; and Fargo, North Dakota.