We start the drive from Joplin to Springfield merging onto Interstate 44 from Interstate 49 in Joplin. Initially driving northeast, we turn east a few miles out of Joplin as we approach the interchange with I-49 north/MO-59 south. Continuing east on I-44, we drive through southwest Missouri countryside, passing Sarcoxie and Stotts City before turning northeast once again just west of Mt. Vernon.
Driving northeast towards Halltown, we pass the interchange with MO-96 (formerly Route 66) before turning east to make our final push into Springfield. Entering Springfield from the southwest, we cross interchanges with MO-360 and MO-266 before turning east once again just past the U.S. Highway 160 interchange in northwest Springfield.
Continuing eastbound in Springfield, we cross the interchanges with MO-13 and Glenstone Ave before ending the video at the interchange with U.S. Highway 65.