We start the video entering the Knoxville metro just east of the Holston River travelling west. Crossing the Holston we soon reach the interchange with U.S. Highway 25W and the junction with Interstate 640. Continuing west, we soon reach downtown and the interchanges with U.S. Highways 441 and 11, as well as Interstate 275 and TN-158. Leaving downtown, we soon cross the western terminus of Interstate 640, which is also signed as Interstate 75. From here until we finish the video at Interstate 140, we are on a co-signed Interstate 40/75.