U.S. Route 219 (US 219) is a north–south United States highway that stretches from Rich Creek, Virginia, to West Seneca, New York, just south of Buffalo. Often referred to as the "North-South Appalachian Highway," US 219 travels through the scenic Appalachian Mountains and serves as an important regional connector in the eastern United States. The route spans approximately 535 miles, passing through six states: Virginia, West Virginia, Maryland, Pennsylvania, and New York.

In the southern portion of its route, US 219 winds through rugged mountainous terrain in West Virginia, providing access to small towns and rural communities. As it progresses north, it briefly overlaps with several other U.S. and state routes, including US 50 and US 33. In Maryland, the route passes near Deep Creek Lake, a popular recreational area. In Pennsylvania, US 219 transforms into a more modern, limited-access highway in some sections, offering a faster route for travelers moving between the interior of the state and the New York border.

In New York, US 219 serves as a major commuter route into the Buffalo metro area. A limited-access expressway segment near the end of the route makes travel more efficient for both local and regional traffic. Although it is not part of the Interstate Highway System, portions of US 219 in Pennsylvania and New York have been upgraded to near-interstate standards.