Ride south on Interstate 75 from Union Centre Blvd in West Chester, Ohio (Exit 19) to Mile Marker 9.5 in Cincinnati.

Notable interchanges:
16 – Interstate 275
15 – Sharon Rd
14 – Glendale
12 – Reading / Lockland
10 – Galbraith Rd
(Northbound I-75 has Exit 10A Ronald Reagan Cross County Hwy – SR-126 / 10B – Galbraith Rd)